PANTHER - Family Information

PANTHER Family Information

Family:

INOSITOL MONOPHOSPHATASE (PTHR20854)

Subfamilies:

PANTHER Links:

Tree MSA

Abstract:

It has been shown that several proteins share two sequence motifs [PMID:1660408]. Two of these proteins, vertebrate and plant inositol monophosphatase (EC: 3.1.3.25), and vertebrate inositol polyphosphate 1-phosphatase (EC: 3.1.3.57), are enzymes of the inositol phosphate second messenger signalling pathway, and share similar enzyme activity. Both enzymes exhibit an absolute requirement for metal ions (Mg²⁺ is preferred), and their amino acid sequences contain a number of conserved motifs, which are also shared by several other proteins related to MPTASE (including products of fungal QaX and qutG, bacterial suhB and cysQ, and yeast hal2) [PMID:7761465]. The function of the other proteins is not yet clear, but it is suggested that they may act by enhancing the synthesis or degradation of phosphorylated messenger molecules [PMID:1660408]. Structural analysis of these proteins has revealed a common core of 155 residues, which includes residues essential for metal binding and catalysis. An interesting property of the enzymes of this family is their sensitivity to Li⁺. The targets and mechanism of action of Li⁺ are unknown, but overactive inositol phosphate signalling may account for symptoms of manic depression [PMID:2553271].

InterPro Accession:

IPR000760

PANTHER Molecular Function:

Phosphatase

Other phosphatase

PANTHER Biological Process:

Biological process unclassified

Pathway Categories:

No pathway information available

Training Sequences:

107

HMM Length

242

Downloads:

HMM (HMMER format)

Genes assigned to this Family

	Total	Celera	FlyBase	NCBI
H. sapiens	11	6	0	5
M. musculus	11	6	0	5
R. norvegicus	10	5	0	5
D. melanogaster	9	0	9	0