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PANTHER Family Information   
Family: ACETYL-COA C-ACYLTRANSFERASE (PTHR18919)
Subfamilies: 18
PANTHER Links:
Tree  Multiple Sequence Alignment
Tree  MSA
Abstract:

Two different types of thiolase [PMID:1755959, PMID:2191949, PMID:1354266] are found both in eukaryotes and in prokaryotes: acetoacetyl-CoA thiolase (EC: 2.3.1.9) and 3-ketoacyl-CoA thiolase (EC: 2.3.1.16). 3-ketoacyl-CoA thiolase (also called thiolase I) has a broad chain-length specificity for its substrates and is involved in degradative pathways such as fatty acid beta-oxidation. Acetoacetyl-CoA thiolase (also called thiolase II) is specific for the thiolysis of acetoacetyl-CoA and involved in biosynthetic pathways such as poly beta-hydroxybutyrate synthesis or steroid biogenesis.

In eukaryotes, there are two forms of 3-ketoacyl-CoA thiolase: one located in the mitochondrion and the other in peroxisomes.

There are two conserved cysteine residues important for thiolase activity. The first located in the N-terminal section of the enzymes is involved in the formation of an acyl-enzyme intermediate; the second located at the C-terminal extremity is the active site base involved in deprotonation in the condensation reaction.

Mammalian nonspecific lipid-transfer protein (nsL-TP) (also known as sterol carrier protein 2) is a protein which seems to exist in two different forms: a 14 Kd protein (SCP-2) and a larger 58 Kd protein (SCP-x). The former is found in the cytoplasm or the mitochondria and is involved in lipid transport; the latter is found in peroxisomes. The C-terminal part of SCP-x is identical to SCP-2 while the N-terminal portion is evolutionary related to thiolases [PMID:1755959].


InterPro Accession: IPR002155
PANTHER Molecular Function: Molecular function unclassified

PANTHER Biological Process: Biological process unclassified

Pathway Categories: No pathway information available
Training Sequences: 124
HMM Length 325
Downloads: HMM (HMMER format)

Genes assigned to this Family
  Total Celera FlyBase NCBI
H. sapiens 12 6 0 6
M. musculus 16 8 0 8
R. norvegicus 16 7 0 9
D. melanogaster 6 0 6 0
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