PANTHER Family Information 
| Family: | BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1 (PTHR13763) | ||
| Subfamilies: | 1 | ||
| PANTHER Links: |
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| Abstract: |
This group represents a DNA-damage repair protein, BRCA1 [PMID:10198641, PMID:8232556]. Germline mutations of the tumour-suppressor gene product BRCA1 lead to 50% familial breast cancer. The protein contains the BRCT C-terminal domain, an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain [PMID:14576433]. |
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| InterPro Accession: | IPR011364 | ||
| PANTHER Molecular Function: |
 Transcription factor Zinc finger transcription factor |
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| PANTHER Biological Process: |
Nucleoside, nucleotide and nucleic acid metabolism DNA metabolism DNA repair mRNA transcription mRNA transcription regulationCell cycle Cell cycle controlOncogenesis Tumor suppressor |
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| Pathway Categories: | No pathway information available | ||
| Training Sequences: |
31
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| HMM Length | 1904 | ||
| Downloads: | HMM (HMMER format) |
Genes assigned to this Family
| Total | Celera | NCBI | |
| H. sapiens | 2 | 1 | 1 |
| M. musculus | 2 | 1 | 1 |
| R. norvegicus | 2 | 1 | 1 |