| Subfamily: | [PROTEIN-PII] URIDYLYLTRANSFERASE (PII URIDYLYL- TRANSFERASE) (URIDYLYL REMOVING ENZYME) (UTASE) (PTHR13734:SF1) | ||
| Family: | TRNA-NUCLEOTIDYLTRANSFERASE/POLY(A) POLYMERASE FAMILY MEMBER | ||
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| Abstract: |
This entry describes GlnD, the uridylyltransferase/uridylyl-removing enzyme for signal-transduction protein PII, and acts as the sensory component of the nitrogen regulation (ntr) system [PMID:11810255]. The ntr system modulates nitrogen metabolism in response to the prevailing nitrogen source and the requirements of the cell. During nitrogen fixation, ammonia and 2-oxoglutarate can be used to produce glutamate. The activity of the PII protein is stimulated by glutamine and inhibited by 2-oxoglutarate. Under glutamate-limiting conditions, PII is uridylylated by GlnD leading to the activation of glutamate synthetase and to the stimulation of NtrC-dependent promoters. Under high concentrations of fixed nitrogen, PII is de-uridylylated leading to the inactivation of the glutamate synthetase pathway and switching off NtrC-dependent promoters [PMID:11065377]. Not all homologues of PII share the property of uridylyltransferase modification on the characteristic Tyr residue (see INTERPRO: IPR002332), but the modification site is preserved in the PII homologue of all species with a member of this family. |
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| InterPro Accession: | IPR010043 | ||
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| Pathway Categories: | No pathway information available | ||
| Training Sequences: |
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| HMM Length | 785 | ||
| Downloads: | HMM (HMMER format) |




