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PANTHER Family Information   
Family: BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE II (PTHR12871)
Subfamilies: 1
PANTHER Links:
Tree  Multiple Sequence Alignment
Tree  MSA
Abstract:

N-acetylglucosaminyltransferase II (EC: 2.4.1.143) is a Golgi resident enzyme that catalyzes an essential step in the biosynthetic pathway leading from high mannose to complex N-linked oligosaccharides [PMID:7797505]. Mutations in the MGAT2 gene lead to a congenital disorder of glycosylation (CDG IIa). CDG IIa patients have an increased bleeding tendency, unrelated to coagulation factors [PMID:11596651].

Synonym(s): UDP-N-acetyl-D-glucosamine:alpha-6-D-mannoside beta-1,2-N- acetylglucosaminyltransferase II, GnT II/MGAT2.


InterPro Accession: IPR007754
PANTHER Molecular Function: Transferase
   Glycosyltransferase

PANTHER Biological Process: Carbohydrate metabolism
Protein metabolism and modification
   Protein modification

Pathway Categories: No pathway information available
Training Sequences: 19
HMM Length 399
Downloads: HMM (HMMER format)

Genes assigned to this Family
  Total Celera FlyBase NCBI
H. sapiens 2 1 0 1
M. musculus 2 1 0 1
R. norvegicus 2 1 0 1
D. melanogaster 1 0 1 0
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