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PANTHER Family Information   
Family: CYTOCHROME C1 HEME LYASE (PTHR12743)
Subfamilies: 1
PANTHER Links:
Tree  Multiple Sequence Alignment
Tree  MSA
Abstract: Cytochrome c heme-lyase (CCHL) (EC: 4.4.1.17) and cytochrome Cc1 heme-lyase (CC1HL) [PMID:1499554] are mitochondrial enzymes that catalyze the covalent attachment of a heme group on two cysteine residues of cytochrome c and c1. These two enzymes are functionally and evolutionary related. There are two conserved regions, the first is located in the central section and the second in the C-terminal section. Both patterns contain conserved histidine, tryptophan and acidic residues which could be important for the interaction of the enzymes with the apoproteins and/or the heme group.
InterPro Accession: IPR000511
PANTHER Molecular Function: Lyase
   Other lyase

PANTHER Biological Process: Protein metabolism and modification
   Protein modification
Coenzyme and prosthetic group metabolism
   Coenzyme metabolism

Pathway Categories: No pathway information available
Training Sequences: 21
HMM Length 337
Downloads: HMM (HMMER format)

Genes assigned to this Family
  Total Celera FlyBase NCBI
H. sapiens 2 1 0 1
M. musculus 2 1 0 1
R. norvegicus 2 1 0 1
D. melanogaster 1 0 1 0
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