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*Now available with Java™ 1.5!*
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| Family: |
GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE (PTHR11999)
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| Subfamilies: |
14
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| PANTHER Links: |
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| Abstract: |
A number of pyridoxal-dependent decarboxylases share regions of sequence similarity, particularly in the vicinity of a conserved lysine residue, which provides the attachment site for the pyridoxal-phosphate (PLP) group [PMID:8181483, PMID:2124279]. Among these enzymes are aromatic-L-amino-acid decarboxylase (L-dopa decarboxylase or tryptophan decarboxylase), which catalyses the decarboxylation of tryptophan to tryptamine [PMID:8889823]; tyrosine decarboxylase, which converts tyrosine into tyramine; and histidine decarboxylase, which catalyses the decarboxylation of histidine to histamine [PMID:2300558]. These enzymes belong to the group II decarboxylases [PMID:8181483, PMID:8889823].
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| InterPro Accession: |
IPR002129
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| PANTHER Molecular Function: |
Lyase
 Decarboxylase
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| PANTHER Biological Process: |
Amino acid metabolism
Other amino acid metabolism
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| Pathway Categories: |
No pathway information available
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| Training Sequences: |
151
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| HMM Length |
564
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| Downloads: |
HMM (HMMER format) |
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Total |
Celera |
FlyBase |
NCBI |
| H. sapiens |
20
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10
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0 |
10
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| M. musculus |
18
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9
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0 |
9
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| R. norvegicus |
16
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8
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0 |
8
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| D. melanogaster |
10
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0 |
10
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0 |
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