PANTHER - Family Information

PANTHER Subfamily Information

Subfamily:

4-AMINOBUTYRATE AMINOTRANSFERASE (PTHR11986:SF6)

Family:

AMINOTRANSFERASE CLASS III

PANTHER Links:

Tree MSA

Abstract:

4-aminobutyrate aminotransferase eukaryotic (EC: 2.6.1.19) is a class III pyridoxal-phosphate-dependent aminotransferase. The enzyme catalyses the conversion of 4-aminobutanoate and 2-oxoglutarate into succinate semialdehyde and L-glutamate. The degree of sequence difference between this set and known bacterial examples is greater than the distance between either set the most similar enzyme with distinct function, and so the prokaryotic and eukaryotic sets have been placed into separate families. This family describes known eukaryotic examples of the enzyme. Alternate names include GABA transaminase, gamma-amino-N-butyrate transaminase, and beta-alanine--oxoglutarate aminotransferase.

InterPro Accession:

IPR004631

PANTHER Molecular Function:

Transferase