PANTHER Family Information 
| Family: | EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED (PTHR11960) | ||
| Subfamilies: | 1 | ||
| PANTHER Links: |
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| Abstract: |
Eukaryotic translation initiation factor 4E (eIF-4E) [PMID:1733496] is a protein that
binds to the cap structure of eukaryotic cellular mRNAs. eIF-4E recognizes and binds
the 7-methylguanosine-containing (m7Gppp) cap during an early step in the initiation
of protein synthesis and facilitates ribosome binding to a mRNA by inducing the unwinding
of its secondary structures. A tryptophan in the central part of the sequence of human
eIF-4E seems to be implicated in cap-binding [PMID:1672854].
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| InterPro Accession: | IPR001040 | ||
| PANTHER Molecular Function: |
 Nucleic acid binding Translation factor Translation initiation factor |
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| PANTHER Biological Process: |
Protein metabolism and modification Protein biosynthesis |
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| Pathway Categories: |
p38 MAPK pathway eukaryotic initiation factor 4E |
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| Training Sequences: |
57
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| HMM Length | 237 | ||
| Downloads: | HMM (HMMER format) |
Genes assigned to this Family
| Total | Celera | FlyBase | NCBI | |
| H. sapiens | 10 | 6 | 0 | 4 |
| M. musculus | 11 | 6 | 0 | 5 |
| R. norvegicus | 11 | 5 | 0 | 6 |
| D. melanogaster | 7 | 0 | 7 | 0 |