PANTHER Family Information 
| Family: | 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE (PTHR11959) | ||
| Subfamilies: | 1 | ||
| PANTHER Links: |
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| Abstract: |
4-hydroxyphenylpyruvate dioxygenase (EC: 1.13.11.27) oxidizes 4-hydroxyphenylpyruvate, a tyrosine and phenylalanine catabolite, to homogentisate. Homogentisate can undergo a further non-enzymatic oxidation and polymerization into brown pigments that protect some bacterial species from light. A similar process occurs spontaneously in blood and is hemolytic [PMID:8000039]. In some bacterial species, this enzyme has been studied as a hemolysin. |
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| InterPro Accession: | IPR005956 | ||
| PANTHER Molecular Function: |
 Oxidoreductase Oxygenase |
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| PANTHER Biological Process: |
Amino acid metabolism Amino acid catabolism |
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| Pathway Categories: | No pathway information available | ||
| Training Sequences: |
32
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| HMM Length | 400 | ||
| Downloads: | HMM (HMMER format) |
Genes assigned to this Family
| Total | Celera | FlyBase | NCBI | |
| H. sapiens | 4 | 2 | 0 | 2 |
| M. musculus | 4 | 2 | 0 | 2 |
| R. norvegicus | 4 | 2 | 0 | 2 |
| D. melanogaster | 1 | 0 | 1 | 0 |