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PANTHER Family Information   
Family: 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE (PTHR11959)
Subfamilies: 1
PANTHER Links:
Tree  Multiple Sequence Alignment
Tree  MSA
Abstract:

4-hydroxyphenylpyruvate dioxygenase (EC: 1.13.11.27) oxidizes 4-hydroxyphenylpyruvate, a tyrosine and phenylalanine catabolite, to homogentisate. Homogentisate can undergo a further non-enzymatic oxidation and polymerization into brown pigments that protect some bacterial species from light. A similar process occurs spontaneously in blood and is hemolytic [PMID:8000039]. In some bacterial species, this enzyme has been studied as a hemolysin.


InterPro Accession: IPR005956
PANTHER Molecular Function: Oxidoreductase
   Oxygenase

PANTHER Biological Process: Amino acid metabolism
   Amino acid catabolism

Pathway Categories: No pathway information available
Training Sequences: 32
HMM Length 400
Downloads: HMM (HMMER format)

Genes assigned to this Family
  Total Celera FlyBase NCBI
H. sapiens 4 2 0 2
M. musculus 4 2 0 2
R. norvegicus 4 2 0 2
D. melanogaster 1 0 1 0
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