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PANTHER Family Information   
Family: UDP- GLUCOSE PYROPHOSPHORYLASE (PTHR11952)
Subfamilies: 2
PANTHER Links:
Tree  Multiple Sequence Alignment
Tree  MSA
Abstract: This family consists of UTP--glucose-1-phosphate uridylyltransferases, EC: 2.7.7.9. Also known as UDP-glucose pyrophosphorylase (UDPGP) and Glucose-1-phosphate uridylyltransferase. UTP--glucose-1-phosphate uridylyltransferase catalyses the interconversion of MgUTP + glucose-1-phosphate and UDP-glucose + MgPPi [PMID:8631325]. UDP-glucose is an important intermediate in mammalian carbohydrate interconversion involved in various metabolic roles depending on tissue type [PMID:8631325]. In Dictyostelium discoideum (slime mold), mutants in this enzyme abort the development cycle [PMID:3035502]. Also within this family is UDP-N-acetylglucosamine pyrophosphorylase (SWISSPROT: Q16222) [PMID:9603950] and two hypothetical proteins from Borrelia burgdorferi, the lyme disease spirochaete (SWISSPROT: O51893 and SWISSPROT: O51036).
InterPro Accession: IPR002618
PANTHER Molecular Function: Transferase
   Nucleotidyltransferase

PANTHER Biological Process: Biological process unclassified

Pathway Categories: No pathway information available
Training Sequences: 81
HMM Length 593
Downloads: HMM (HMMER format)

Genes assigned to this Family
  Total Celera FlyBase NCBI
H. sapiens 7 4 0 3
M. musculus 6 2 0 4
R. norvegicus 8 4 0 4
D. melanogaster 2 0 2 0
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