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PANTHER Family Information   
Family: NADP-SPECIFIC ISOCITRATE DEHYDROGENASE (PTHR11822)
Subfamilies: 1
PANTHER Links:
Tree  Multiple Sequence Alignment
Tree  MSA
Abstract:

Isocitrate dehydrogenase (IDH) [PMID:2682654, PMID:1939242] is an important enzyme of carbohydrate metabolism which catalyzes the oxidative decarboxylation of isocitrate into alpha-ketoglutarate. IDH is either dependent on NAD+ (EC: 1.1.1.41) or on NADP+ (EC: 1.1.1.42). In eukaryotes there are at least three isozymes of IDH: two are located in the mitochondrial matrix (one NAD+-dependent, the other NADP+-dependent), while the third one (also NADP+-dependent) is cytoplasmic. In Escherichia coli the activity of a NADP+-dependent form of the enzyme is controlled by the phosphorylation of a serine residue; the phosphorylated form of IDH is completely inactivated.

The eukaryotic, NADP-dependent isocitrate dehydrogenases, are defined by this group that includes the cytosolic, mitochondrial, and chloroplast enzymes, but does also hit a small number of bacterial proteins.


InterPro Accession: IPR004790
PANTHER Molecular Function: Oxidoreductase
   Dehydrogenase

PANTHER Biological Process: Carbohydrate metabolism
   Tricarboxylic acid pathway

Pathway Categories: TCA cycle
   Isocitrate Dehydrogenase
Training Sequences: 55
HMM Length 472
Downloads: HMM (HMMER format)

Genes assigned to this Family
  Total Celera FlyBase NCBI
H. sapiens 5 3 0 2
M. musculus 4 2 0 2
R. norvegicus 4 2 0 2
D. melanogaster 1 0 1 0
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