| Subfamily: | HYALURONIDASE 1 (SPERM ADHESION MOLECULE 1) (PTHR11769:SF4) | ||
| Family: | HYALURONIDASE | ||
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| Abstract: |
O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [PMID:7624375, PMID:8535779, PUB00005672]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site [PUB00007032]. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in 'clans'. O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [PMID:1747104, PMID:8352747, PMID:8687420, PMID:1732212, PMID:8535779, PUB00005672]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site [PUB00007032]. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in 'clans'. Family 56 (CAZY: GH_56) encompasses a group of hyaluronidases (EC: 3.2.1.35) that includes venom hyaluronidases and mammalian sperm surface proteins (PH-20). PH-20 is required for sperm adhesion to the egg zona pellucida; it is located on both the sperm plasma membrane and acrosomal membrane [PMID:2269661]. During fertilisation, sperm must first penetrate a layer of cumulus cells that surrounds the egg, before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid, which is formed prior to ovulation. PH-20 facilitates penetration of the cumulus cell layer by digesting hyaluronic acid. The amino acid sequence of the mature protein contains 468 amino acids, and includes six potential N-linked glycosylation sites and twelve cysteines, eight of which are tightly clustered near the C-terminus [PMID:2269661]. |
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| InterPro Accession: | IPR001439 | ||
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| Pathway Categories: | No pathway information available | ||
| Training Sequences: |
11
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| HMM Length | 501 | ||
| Downloads: | HMM (HMMER format) |
| Total | Celera | NCBI | |
| H. sapiens | 2 | 1 | 1 |
| M. musculus | 4 | 2 | 2 |
| R. norvegicus | 4 | 2 | 2 |




