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PANTHER Family Information   
Family: LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (PTHR11717)
Subfamilies: 4
PANTHER Links:
Tree  Multiple Sequence Alignment
Tree  MSA
Abstract: Low molecular weight (LMW) phosphotyrosine protein phosphatase (or acid phosphatase) acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates [PMID:1587862, PMID:1304913]. It is a cytoplasmic enzyme that catalyses the reaction: protein tyrosine phosphate + H2O = protein tyrosine + Pi The structure of the protein has been solved by X-ray crystallography [PMID:8052313] and is found to form a single structural domain. It belongs to the alpha/beta class, with 6 alpha-helices and 4 beta-strands forming a 3-layer alpha-beta-alpha sandwich architecture.
InterPro Accession: IPR000106
PANTHER Molecular Function: Molecular function unclassified

PANTHER Biological Process: Biological process unclassified

Pathway Categories: No pathway information available
Training Sequences: 50
HMM Length 149
Downloads: HMM (HMMER format)

Genes assigned to this Family
  Total Celera FlyBase NCBI
H. sapiens 4 2 0 2
M. musculus 13 7 0 6
R. norvegicus 7 2 0 5
D. melanogaster 4 0 4 0
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