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*Now available with Java™ 1.5!*
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| Family: |
POLYKETIDE SYNTHASE-RELATED (PTHR11712)
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| Subfamilies: |
6
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| PANTHER Links: |
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| Abstract: |
Beta-ketoacyl-ACP synthase (EC: 2.3.1.41) (KAS) [PMID:3076376] is the enzyme that catalyzes
the condensation of malonyl-ACP with the growing fatty acid chain. It is found as a component
of a number of enzymatic systems, including fatty acid synthetase (FAS), which catalyzes the
formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH; the
multi-functional 6-methysalicylic acid synthase (MSAS) from Penicillium patulum [PMID:2209605], which is
involved in the biosynthesis of a polyketide antibiotic; polyketide antibiotic synthase enzyme
systems; Emericella nidulans multifunctional protein Wa, which is involved in the biosynthesis
of conidial green pigment; Rhizobium nodulation protein nodE, which probably acts as a
beta-ketoacyl synthase in the synthesis of the nodulation Nod factor fatty acyl chain; and yeast
mitochondrial protein CEM1. The condensation reaction is a two step process, first the acyl
component of an activated acyl primer is transferred to a cysteine residue of the enzyme and
is then condensed with an activated malonyl donor with the concomitant release of carbon
dioxide.
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| InterPro Accession: |
IPR000794
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| PANTHER Molecular Function: |
Molecular function unclassified
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| PANTHER Biological Process: |
Biological process unclassified
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| Pathway Categories: |
No pathway information available
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| Training Sequences: |
136
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| HMM Length |
2404
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| Downloads: |
HMM (HMMER format) |
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Total |
Celera |
FlyBase |
NCBI |
| H. sapiens |
6
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2
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0 |
4
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| M. musculus |
4
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2
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0 |
2
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| R. norvegicus |
5
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2
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0 |
3
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| D. melanogaster |
4
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0 |
4
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0 |
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