Home     Browse     Genes     Families and HMMs     Pathways     Ontologies     Tools     Workspace  
  Search Families     Download HMMs  
 
PANTHER Family Information   
Family: ALCOHOL DEHYDROGENASE RELATED (PTHR11695)
Subfamilies: 27
PANTHER Links:
Tree  Multiple Sequence Alignment
Tree  MSA
Abstract: Alcohol dehydrogenase (EC: 1.1.1.1) (ADH) catalyzes the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD: Ethanol + NAD = Acetaldehyde + NADH Currently three structurally and catalytically different types of alcohol dehydrogenases are known:
  1. Zinc-containing 'long-chain' alcohol dehydrogenases.
  2. Insect-type, or 'short-chain' alcohol dehydrogenases.
  3. Iron-containing alcohol dehydrogenases.
Zinc-containing ADH's [PMID:3622514, PMID:1593644] are dimeric or tetrameric enzymes that bind two atoms of zinc per subunit. One of the zinc atom is essential for catalytic activity while the other is not. Both zinc atoms are coordinated by either cysteine or histidine residues; the catalytic zinc is coordinated by two cysteines and one histidine. Zinc-containing ADH's are found in bacteria, mammals, plants, and in fungi. In most species there are more than one isozyme (for example, human have at least six isozymes, yeast have three, etc.). A number of other zinc-dependent dehydrogenases are closely related to zinc ADH [PMID:8504864] and are included in this family.

In addition, this family includes NADP-dependent quinone oxidoreductase (EC: 1.6.5.5), an enzyme found in bacteria (gene qor), in yeast and in mammals where, in some species such as rodents, it has been recruited as an eye lens protein and is known as zeta-crystallin [PMID:8486156]. The sequence of quinone oxidoreductase is distantly related to that other zinc-containing alcohol dehydrogenases and it lacks the zinc-ligand residues. The torpedo fish and mammalian synaptic vesicle membrane protein vat-1 is related to qor.


InterPro Accession: IPR002085
PANTHER Molecular Function: Oxidoreductase
   Dehydrogenase
   Reductase

PANTHER Biological Process: Carbohydrate metabolism
   Other carbohydrate metabolism
Other metabolism
   Other carbon metabolism

Pathway Categories: No pathway information available
Training Sequences: 502
HMM Length 525
Downloads: HMM (HMMER format)

Genes assigned to this Family
  Total Celera FlyBase NCBI
H. sapiens 43 22 0 21
M. musculus 44 23 0 21
R. norvegicus 33 17 0 16
D. melanogaster 7 0 7 0
About   |   Contact Us   |   System Requirements   |   Privacy Policy   |   Disclaimer
© Copyright 2007 SRI International. All Rights Reserved.