PANTHER Family Information 
| Family: | BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN (PTHR11692) | ||
| Subfamilies: | 1 | ||
| PANTHER Links: |
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| Abstract: |
This is a family of bifunctional enzymes catalysing the last two steps in de novo purine biosynthesis. The bifunctional enzyme is found in both prokaryotes and eukaryotes. The second last step is catalysed by 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase EC: 2.1.2.3 (AICARFT), this enzyme catalyses the formylation of AICAR with 10-formyl-tetrahydrofolate to yield FAICAR and tetrahydrofolate [PMID:9332377]. The last step is catalysed by IMP (Inosine monophosphate) cyclohydrolase EC: 3.5.4.10 (IMPCHase), cyclizing FAICAR (5-formylaminoimidazole-4-carboxamide ribonucleotide) to IMP [PMID:9332377].
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| InterPro Accession: | IPR002695 | ||
| PANTHER Molecular Function: |
 Transferase MethyltransferaseHydrolase Other hydrolase |
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| PANTHER Biological Process: |
Nucleoside, nucleotide and nucleic acid metabolism Purine metabolism |
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| Pathway Categories: |
De novo purine biosynthesis AICAR transformylaseDe novo purine biosynthesis IMP cyclohydrolase |
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| Training Sequences: |
40
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| HMM Length | 608 | ||
| Downloads: | HMM (HMMER format) |
Genes assigned to this Family
| Total | Celera | FlyBase | NCBI | |
| H. sapiens | 2 | 1 | 0 | 1 |
| M. musculus | 4 | 3 | 0 | 1 |
| R. norvegicus | 3 | 1 | 0 | 2 |
| D. melanogaster | 1 | 0 | 1 | 0 |