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PANTHER Family Information   
Family: FRUCTOSE-BISPHOSPHATE ALDOLASE (PTHR11627)
Subfamilies: 1
PANTHER Links:
Tree  Multiple Sequence Alignment
Tree  MSA
Abstract:

Fructose-bisphosphate aldolase (EC: 4.1.2.13) [PMID:2199259, PMID:1412694] is a glycolytic enzyme that catalyses the reversible aldol cleavage or condensation of fructose-1,6-bisphosphate into dihydroxyacetone-phosphate and glyceraldehyde 3-phosphate. There are two classes of fructose-bisphosphate aldolases with different catalytic mechanisms: class I enzymes [PMID:3355497] are found in animals, do not require a metal ion, and are characterised by the formation of a Schiff base intermediate between a highly conserved active site lysine and a substrate carbonyl group, while the class II enzymes are produced in bacteria and fungi, and require an active-site divalent metal ion. This entry represents the class I enzymes.

In vertebrates, three forms of this enzyme are found: aldolase A is expressed in muscle, aldolase B in liver, kidney, stomach and intestine, and aldolase C in brain, heart and ovary. The different isozymes have different catalytic functions: aldolases A and C are mainly involved in glycolysis, while aldolase B is involved in both glycolysis and gluconeogenesis. Defects in aldolase B result in hereditary fructose intolerance.


InterPro Accession: IPR000741
PANTHER Molecular Function: Lyase
   Aldolase

PANTHER Biological Process: Carbohydrate metabolism
   Glycolysis

Pathway Categories: Fructose galactose metabolism
   Fructose bisphosphate aldolase
Glycolysis
   Aldolase
Training Sequences: 78
HMM Length 373
Downloads: HMM (HMMER format)

Genes assigned to this Family
  Total Celera FlyBase NCBI
H. sapiens 8 5 0 3
M. musculus 17 14 0 3
R. norvegicus 12 6 0 6
D. melanogaster 2 0 2 0
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