PANTHER Family Information 
| Family: | PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7 (PTHR11609) | ||
| Subfamilies: | 3 | ||
| PANTHER Links: |
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| Abstract: |
Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC: 6.3.2.6) (SAICAR synthetase) catalyzes the seventh step in the de novo purine biosynthetic pathway; the ATP-dependent conversion of 5'-phosphoribosyl-5-aminoimidazole-4-carboxylic acid and aspartic acid to SAICAR [PMID:1574589]. In bacteria (purC), fungi (ADE1) and plants (Pur7), SAICAR synthetase is a monofunctional protein; in animals it is the N-terminal domain of a bifunctional enzyme that also catalyse phosphoribosylaminoimidazole carboxylase (AIRC) activity (see INTERPRO: IPR000031). |
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| InterPro Accession: | IPR001636 | ||
| PANTHER Molecular Function: |
 Synthase and synthetase SynthaseLigase |
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| PANTHER Biological Process: |
Nucleoside, nucleotide and nucleic acid metabolism Purine metabolism |
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| Pathway Categories: | No pathway information available | ||
| Training Sequences: |
33
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| HMM Length | 387 | ||
| Downloads: | HMM (HMMER format) |
Genes assigned to this Family
| Total | Celera | FlyBase | NCBI | |
| H. sapiens | 4 | 3 | 0 | 1 |
| M. musculus | 9 | 8 | 0 | 1 |
| R. norvegicus | 3 | 2 | 0 | 1 |
| D. melanogaster | 2 | 0 | 2 | 0 |