PANTHER - Family Information

PANTHER Family Information

Family:

ARGININE OR CREATINE KINASE (PTHR11547)

Subfamilies:

PANTHER Links:

Tree MSA

Abstract:

ATP:guanido phosphotransferases are a family of structurally and functionally related enzymes [PMID:2324092, PMID:7819288] that reversibly catalyze the transfer of phosphate between ATP and various phosphogens. The enzymes belonging to this family include glycocyamine kinase (EC: 2.7.3.1), which catalyzes the transfer of phosphate from ATP to guanidoacetate; arginine kinase (EC: 2.7.3.3), which catalyzes the transfer of phosphate from ATP to arginine; taurocyamine kinase (EC: 2.7.3.4), an annelid-specific enzyme that catalyzes the transfer of phosphate from ATP to taurocyamine; lombricine kinase (EC: 2.7.3.5), an annelid-specific enzyme that catalyzes the transfer of phosphate from ATP to lombricine; Smc74, a cercaria-specific enzyme from Schistosoma mansoni [PMID:2324092]; and creatine kinase (EC: 2.7.3.2) (CK) [PMID:3896131, PMID:2324105], which plays an important role in energy metabolism of vertebrates. It catalyzes the reversible transfer of high energy phosphate from ATP to creatine, generating phosphocreatine and ADP. There are at least four different, but very closely related, forms of CK. Two isozymes, M (muscle) and B (brain), are cytosolic, while the other two are mitochondrial. In sea urchin there is a flagellar isozyme, which consists of the triplication of a CK-domain. A cysteine residue is implicated in the catalytic activity of these enzymes and the region around this active site residue is highly conserved.

InterPro Accession:

IPR000749

PANTHER Molecular Function:

Molecular function unclassified

PANTHER Biological Process:

Biological process unclassified

Pathway Categories:

No pathway information available

Training Sequences:

HMM Length

325

Downloads:

HMM (HMMER format)

Genes assigned to this Family

	Total	Celera	FlyBase	NCBI
H. sapiens	12	5	0	7
M. musculus	11	6	0	5
R. norvegicus	7	4	0	3
D. melanogaster	4	0	4	0