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*Now available with Java™ 1.5!*
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| Family: |
RIBONUCLEASE (PTHR11437)
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| Subfamilies: |
9
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| PANTHER Links: |
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| Abstract: |
Pancreatic ribonucleases (RNAse) are pyrimidine-specific endonucleases
found in high quantity in the pancreas of certain mammals and of
some reptiles [PMID:3940901]. Specifically, the enzymes are involved in endonucleolytic
cleavage of 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending
in C-P or U-P with 2',3'-cyclic phosphate intermediates. Ribonuclease can
unwind the DNA helix by complexing with single-stranded DNA; the complex
arises by an extended multi-site cation-anion interaction between lysine
and arginine residues of the enzyme and phosphate groups of the nucleotides.
Other proteins belonging to the pancreatic RNAse family include: bovine
seminal vesicle and brain ribonucleases; kidney non-secretory ribonucleases
[PMID:2734298]; liver-type ribonucleases [PMID:2611266]; angiogenin, which induces vascularisation
of normal and malignant tissues; eosinophil cationic protein [PMID:2473157], a
cytotoxin and helminthotoxin with ribonuclease activity; and frog liver
ribonuclease and frog sialic acid-binding lectin.
The sequence of pancreatic RNases contains four conserved disulphide bonds and
three amino acid residues involved in the catalytic activity.
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| InterPro Accession: |
IPR001427
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| PANTHER Molecular Function: |
Nucleic acid binding Nuclease Endoribonuclease
Hydrolase
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| PANTHER Biological Process: |
Nucleoside, nucleotide and nucleic acid metabolism RNA catabolism
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| Pathway Categories: |
No pathway information available
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| Training Sequences: |
88
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| HMM Length |
162
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| Downloads: |
HMM (HMMER format) |
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