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PANTHER Family Information   
Family: RIBONUCLEASE T2 (PTHR11240)
Subfamilies: 2
PANTHER Links:
Tree  Multiple Sequence Alignment
Tree  MSA
Abstract:

The fungal ribonucleases T2 from Aspergillus oryzae, M from Aspergillus saitoi and Rh from Rhizopus niveus are structurally and functionally related 30 Kd glycoproteins [PMID:2229029] that cleave the 3'-5' internucleotide linkage of RNA via a nucleotide 2',3'-cyclic phosphate intermediate (EC: 3.1.27.1).

Two histidines residues have been shown [PMID:2298207, PMID:1633875] to be involved in the catalytic mechanism of RNase T2 and Rh. These residues and the region around them are highly conserved in a number of other RNAses that have been found to be evolutionary related to these fungal enzymes.


InterPro Accession: IPR001568
PANTHER Molecular Function: Molecular function unclassified

PANTHER Biological Process: Biological process unclassified

Pathway Categories: No pathway information available
Training Sequences: 30
HMM Length 250
Downloads: HMM (HMMER format)

Genes assigned to this Family
  Total Celera FlyBase NCBI
H. sapiens 2 1 0 1
R. norvegicus 3 2 0 1
D. melanogaster 1 0 1 0
M. musculus 1 0 0 1
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