PANTHER Family Information 
| Family: | RIBONUCLEASE T2 (PTHR11240) | ||
| Subfamilies: | 2 | ||
| PANTHER Links: |
|
||
| Abstract: |
The fungal ribonucleases T2 from Aspergillus oryzae, M from Aspergillus saitoi and Rh from Rhizopus niveus are structurally and functionally related 30 Kd glycoproteins [PMID:2229029] that cleave the 3'-5' internucleotide linkage of RNA via a nucleotide 2',3'-cyclic phosphate intermediate (EC: 3.1.27.1). Two histidines residues have been shown [PMID:2298207, PMID:1633875] to be involved in the catalytic mechanism of RNase T2 and Rh. These residues and the region around them are highly conserved in a number of other RNAses that have been found to be evolutionary related to these fungal enzymes. |
||
| InterPro Accession: | IPR001568 | ||
| PANTHER Molecular Function: |
 Molecular function unclassified |
||
| PANTHER Biological Process: |
Biological process unclassified |
||
| Pathway Categories: | No pathway information available | ||
| Training Sequences: |
30
|
||
| HMM Length | 250 | ||
| Downloads: | HMM (HMMER format) |
Genes assigned to this Family
| Total | Celera | FlyBase | NCBI | |
| H. sapiens | 2 | 1 | 0 | 1 |
| R. norvegicus | 3 | 2 | 0 | 1 |
| D. melanogaster | 1 | 0 | 1 | 0 |
| M. musculus | 1 | 0 | 0 | 1 |