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PANTHER Family Information   
Family: RETICULON/NOGO (PTHR10994)
Subfamilies: 23
PANTHER Links:
Tree  Multiple Sequence Alignment
Tree  MSA
Abstract:

Eukaryotic proteins of the reticulon (RTN) family all share an association with the endoplasmic reticulum (ER). Whereas amino-terminal regions are not related to one another, all reticulon proteins share a 200 amino acid residue region of sequence similarity at the C-terminal. This region contains two large hydrophobic regions separated by a 66 residue hydrophilic segment. The conserved hydrophobic C-terminal portion has been shown to play an essential role in the association of reticulons with the ER membrane. The hydrophobic portions are supposed to be membrane-embedded and the hydrophilic 66 residue localized to the lumenal/extracellular face of the membrane. Most reticulons have a di-lysine ER retention motif at the C-terminal. Because of their likely association with the rough as well as the smooth ER, the reticulons might play some role in transport processes or in regulation of intracellular calcium levels. It has been suggested that the reticulons may be serving as ER-associated channel-like complexes [PMID:7844160, PMID:8833145, PMID:9693037, PMID:10667797].


InterPro Accession: IPR003388
PANTHER Molecular Function: Molecular function unclassified

PANTHER Biological Process: Biological process unclassified

Pathway Categories: No pathway information available
Training Sequences: 160
HMM Length 591
Downloads: HMM (HMMER format)

Genes assigned to this Family
  Total Celera FlyBase NCBI
H. sapiens 11 6 0 5
M. musculus 10 5 0 5
R. norvegicus 10 5 0 5
D. melanogaster 2 0 2 0
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