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PANTHER Family Information   
Family: DEOXYRIBOSE-PHOSPHATE ALDOLASE (PTHR10889)
Subfamilies: 1
PANTHER Links:
Tree  Multiple Sequence Alignment
Tree  MSA
Abstract:

Class I aldolases catalyse carbon-carbon bond formation using a 'Schiff base' mechanism. This entry represents deoxyribose-phosphate aldolase, a widely distributed enzyme, which catalyses the following reversible reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde While the physiological role of this enzyme remains unknown in eukaryotes, in prokaroytes it is thought to function in the catabolism of deoxyribonucleotides [PMID:1730028, PMID:4923156].

In all studied structures, the deoxyribose-phophate aldolase subunits adopt the classical eight-bladed TIM barrel fold [PMID:15388928, PMID:11598300, PMID:12529358]. The oligomerisation state of the enzyme appears to depend on the living temperature of the organism - the Escherichia coli enzyme (SWISSPROT: P0A6L0) is a homodimer, while the enzymes from the thermophilic microorganisms Thermus thermophilus and Aeropyrum pernix (SWISSPROT: Q9Y948) are homotetramers. The degree of oligomerisation does not, however, appear to affect catalysis.


InterPro Accession: IPR011343
PANTHER Molecular Function: Lyase
   Aldolase

PANTHER Biological Process: Nucleoside, nucleotide and nucleic acid metabolism

Pathway Categories: No pathway information available
Training Sequences: 20
HMM Length 317
Downloads: HMM (HMMER format)

Genes assigned to this Family
  Total Celera FlyBase NCBI
H. sapiens 2 1 0 1
M. musculus 2 1 0 1
R. norvegicus 2 1 0 1
D. melanogaster 1 0 1 0
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