HDAs function in multi-subunit complexes, reversing the acetylation of histones by histone acetyltransferases [PMID:10322454, PMID:10072350], and are also believed to deacetylate general transcription factors such as TFIIF and sequence-specific transcription factors such as p53 [PMID:10322454]. Thus, HDAs contribute to the regulation of transcription, in particular transcriptional repression [PMID:10072350]. At N-terminal tails of histones, removal of the acetyl group from the epsilon-amino group of a lysine side chain will restore its positivecharge, which may stabilise the histone-DNA interaction and prevent activating transcription factors binding to promoter elements [PMID:9278492]. HDAs play important roles in the cell cycle and differentiation, and their deregulation can contribute to the development of cancer [PMID:10072350, PMID:10322142].

HDAs function in multi-subunit complexes, reversing the acetylation of histones by histone acetyltransferases [PMID:10322454, PMID:10072350], and are also believed to deacetylate general transcription factors such as TFIIF and sequence- specific transcription factors such as p53 [PMID:10322454]. Thus, HDAs contribute to the regulation of transcription, in particular transcriptional repression. At N-terminal tails of histones, removal of the acetyl group from the epsilon-amino group of a lysine side chain will restore its positive charge, which may stabilise the histone-DNA interaction and prevent activating transcription factors binding to promoter elements [PMID:9278492]. HDAs play important roles in the cell cycle and differentiation, and their deregulation can contribute to the development of cancer [PMID:10072350, PMID:10322142].