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PANTHER Family Information   
Family: DNA POLYMERASE B FAMILY MEMBER (PTHR10322)
Subfamilies: 5
PANTHER Links:
Tree  Multiple Sequence Alignment
Tree  MSA
Abstract:

DNA is the biological information that instructs cells how to exist in an ordered fashion: accurate replication is thus one of the most important events in the life cycle of a cell. This function is performed by DNA- directed DNA-polymerases (EC: 2.7.7.7) by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA, using a complementary DNA chain as a template. Small RNA molecules are generally used as primers for chain elongation, although terminal proteins may also be used for the de novo synthesis of a DNA chain. Even though there are 2 different methods of priming, these are mediated by 2 very similar polymerases classes, A and B, with similar methods of chain elongation.

A number of DNA polymerases have been grouped under the designation of DNA polymerase family B. Six regions of similarity (numbered from I to VI) are found in all or a subset of the B family polymerases. The most conserved region (I) includes a conserved tetrapeptide with two aspartate residues. Its function is not yet known. However, it has been suggested [PMID:2461550] that it may be involved in binding a magnesium ion. All sequences in the B family contain a characteristic DTDS motif, and possess many functional domains, including a 5'-3' elongation domain, a 3'-5' exonuclease domain [PMID:8679562], a DNA binding domain, and binding domains for both dNTP's and pyrophosphate [PMID:9757117].


InterPro Accession: IPR006172
PANTHER Molecular Function: Nucleic acid binding
   DNA-directed DNA polymerase

PANTHER Biological Process: Biological process unclassified

Pathway Categories: No pathway information available
Training Sequences: 94
HMM Length 1118
Downloads: HMM (HMMER format)

Genes assigned to this Family
  Total Celera FlyBase NCBI
H. sapiens 8 4 0 4
M. musculus 8 4 0 4
R. norvegicus 8 4 0 4
D. melanogaster 3 0 3 0
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