| Family: | ALPHA-L-FUCOSIDASE (PTHR10030) | ||
| Subfamilies: | 1 | ||
| PANTHER Links: |
|
||
| Abstract: |
O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [PMID:7624375, PMID:8535779, PUB00005672]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site [PUB00007032]. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in 'clans'. O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [PMID:1747104, PMID:8352747, PMID:8687420, PMID:1732212, PMID:8535779, PUB00005672]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site [PUB00007032]. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in 'clans'. Family 29 (CAZY: GH_29) encompasses alpha-L-fucosidases (EC: 3.2.1.51) [PMID:2482732], which is a lysosomal enzyme responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. Deficiency of alpha-L-fucosidase results in the lysosomal storage disease fucosidosis. |
||
| InterPro Accession: | IPR000933 | ||
| PANTHER Molecular Function: |
|
||
| PANTHER Biological Process: |
|
||
| Pathway Categories: | No pathway information available | ||
| Training Sequences: |
45
|
||
| HMM Length | 305 | ||
| Downloads: | HMM (HMMER format) |
| Total | Celera | FlyBase | NCBI | |
| H. sapiens | 4 | 2 | 0 | 2 |
| M. musculus | 4 | 2 | 0 | 2 |
| R. norvegicus | 4 | 2 | 0 | 2 |
| D. melanogaster | 1 | 0 | 1 | 0 |




