PANTHER - Protein Classification System

PANTHER version 6.1 contains 5547 protein families, divided into 24,582 functionally distinct protein subfamilies by expert biologist curators. Each protein family is represented by a phylogenetic tree defining its subfamilies. Families and subfamilies are also represented by HMMs and associated with functional ontology terms. For PANTHER version 6.1, the UniProt protein database was clustered using a BLAST-based similarity score, and the resulting dendrogram was used to define the protein families (Mi et al., 2005).

Search for Panther families, trees and HMMs. Browse the PANTHER/X ontology of protein function. Search pre-calculated HMM scores for human, rat, mouse and Drosophila genes. Interactively score a new sequence against PANTHER HMMs. Download software to score many sequences against PANTHER HMMs.