Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios

Andrew G. Clark1, Stephen Glanowski2, Rasmus Nielsen3, Paul D. Thomas4, Anish Kejariwal4, Melissa A. Todd3, David M. Tanenbaum5, Daniel Civello6, Fu Lu5, Brian Murphy2, Steve Ferriera2, Gary Wang2, Xianqgun Zheng5, Thomas J. White6, John J. Sninsky6, Mark D. Adams7, Michele Cargill6* 1Molecular Biology & Genetics, Cornell University, Ithaca, NY 148153, USA 2Applied Biosystems, 45 West Gude Dr., Rockville, MD 20850, USA 3Biological Statistics & Computational Biology, Cornell University, Ithaca, NY 14853 4Protein Informatics, Celera Genomics, 850 Lincoln Centre Dr., Foster City, CA 94404, USA 5Celera Genomics, 45 West Gude Dr., Rockville, MD 20850, USA 6Celera Diagnostics, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA 7Deptartment of Genetics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA *To whom correspondence should be sent: michele_cargill@celeradiagnostics.com Science 2003 December 12; 302: 1960-1963.

Supplementary Materials
DatabaseS1
	7645 human-mouse-chimp coding sequence alignments
DatabaseS2
	Text file of all data used in the analysis